Author + information
- Gordon R. Reeves,
- David Whellan,
- Jonathan Rich,
- Stephen Gottlieb,
- Andrew Kao,
- Paul Mather,
- Brack Hattler and
- Christopher O'Connor
Background: Patients recovering from acute heart failure (AHF) suffer severe physical function impairments. Sleep disordered breathing (SDB) is common in patients with AHF and may adversely impact recovery. We hypothesized that treatment of SDB with adaptive servo-ventilation (ASV) would improve physical activity (PA) following AHF hospitalization.
Methods: Accelerometers were worn by 39 participants in this sub study of the CAT-HF trial, which was stopped before fully enrolled. Enrollees hospitalized with AHF and untreated SDB were randomized to ASV therapy or usual care. PA outcomes were compared between the two study arms for 1 week intervals immediately, 1 month and 6 months following hospital discharge with repeated measures ANOVA; restricted maximum likelihood was used for missing values.
Results: Baseline characteristics were similar between study arms. Average daily minutes of PA, energy expenditure and step count (Figure) were not significantly different in the ASV arm compared to usual care at 1 month or 6 months (p>0.2 for all). Average daily PA remained severely impaired in both cohorts through 6 months: <2.5 hours of any activity (>1.5 METS), ≤15 minutes of moderate-vigorous activity (>3 METS) and <2,000 steps.
Conclusions: PA is severely impaired following AHF hospitalization in patients with SDB and remains so even 6 months later. ASV therapy did not have a detectable impact on PA in this limited sample. Novel interventions to improve PA in patients recovering from AHF with SDB are needed.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Acute Heart Failure: Evaluating Strategies to Prevent Readmissions
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1163-289
- 2017 American College of Cardiology Foundation