Author + information
- Konstantin A. Krychtiuk,
- Max Lenz,
- Kurt Huber,
- Johann Wojta,
- Gottfried Heinz and
- Walter Speidl
Background: Patients suffering from acute heart failure (AHF) requiring admission to an intensive care unit (ICU) have a poor prognosis. Activation of the innate immune system contributes to the pathogenesis of AHF. Mitochondrial DNA that shows similarities to bacterial DNA may be released after tissue damage and activates the innate immune system. Therefore, the aim of this study was to analyze whether circulating levels of mtDNA predict 30-day survival in patients with AHF.
Methods: We included 90 consecutive patients with AHF admitted to our cardiovascular ICU (33% with cardiogenic shock, 21% with acutely decompensated HF and 46% of patients suffered from AHF after cardiac arrest). Blood was taken at admission and mtDNA levels were measured by real-time PCR.
Results: Mean age was 62.1 ± 16.0, 76.7% of patients were male and median NT-proBNP levels were 4986 (1525 – 23842) pg/mL. 30-day survival was 64.4%. Median mitochondrial DNA levels at admission were significantly higher in non-survivors when compared with survivors (29.6 (12.1 – 70.7) ng/mL vs. 20.6 (7.3-37.1 ng/mL), p<0.05). Patients with plasma levels of mtDNA in the highest quartile had a 2.6-fold higher risk of dying after adjustment for age, gender, NT-proBNP levels and APACHE II score (p<0.05).
Conclusions: Circulating levels of mtDNA predict mortality in AHF patients requiring ICU admission.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Acute Heart Failure: Evaluating Strategies to Prevent Readmissions
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1163-290
- 2017 American College of Cardiology Foundation