Author + information
- Stefan Kastl,
- Konstantin Krychtiuk,
- Lenz Max,
- Johann Wojta,
- Gottfried Heinz and
- Walter Speidl
Aims: Acute heart failure (AHF) and cardiogenic shock (CS) are associated with an impaired intestinal perfusion which leads to a release of cytoplasmatic proteins by hypoxic epithelial injury. Intestinal fatty acid binding protein (iFABP), which is very specific for the mature enterocyte, could be a useful new and very sensitive biomarker for reduced gut perfusion that may be associated with outcome of patients with AHF or CS. The aim of this study was to investigate whether circulating levels of iFABP are associated with mortality in patients with AHF or CS that require admission to an intensive care unit (ICU).
Methods and Results: We included 90 consecutive patients with AHF or cardiogenic shock admitted to a cardiacICU Mean age was 62.1 ± 16.0, 76.7% of patients were male and median NT-proBNP levels were 4986 (1525 – 23842) pg/mL. 30-day survival was 64.4%. Patients who died showed significantly higher levels of iFABP at admission as compared to survivors (239.7 IQR 105.8 – 479.6 pg/mL vs. 286.0 IQR 206.2 – 3413.9 pg/mL; p=0.008). Patients with serum levels of iFABP in the highest quartile (iFABP ≥ 588.4 pg/mL) had a 2.7-fold risk (p=0.008) of dying as compared to patients in the first quartiles independently of demographics, NT-proBNP and vasopressor use.
Conclusions: Circulating levels of iFABP are associated with mortality suggesting that intestinal perfusion is associated with outcome in patients with AHF or CS that require ICU admission.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Acute Heart Failure: Evaluating Strategies to Prevent Readmissions
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1163-291
- 2017 American College of Cardiology Foundation