Author + information
- Shangyu Liu,
- Jiarui Mi,
- Shengwen Yang,
- Wei Hua,
- Zhimin Liu and
- Shu Zhang
Background: The functionality of high density lipoprotein cholesterol (HDL-C) is impaired in heart failure (HF). The study is to assess the role of serum HDL-C level on long-term clinical outcomes in patients receiving cardiac resynchronization therapy (CRT).
Methods: A total of 364 consecutive single-center patients with CRT between January 2010 and December 2015 were retrospectively enrolled and categorized into 3 groups based on serum HDL-C level (HDL-C ≤ 0.90mmol/L, 0.91 to 1.11mmol/L, ≥ 1.12mmol/L). Rehospitalization due to worsening HF or all-cause mortality (including heart transplantation) was analyzed using Kaplan-Meier curves and log-rank test. Serum HDL-C level was evaluated in Cox proportional-hazards regression models as an independent prognostic factor.
Results: After undergoing median 22-months follow-up, 48 (13.1%) patients died, 6 (1.6%) underwent heart transplantation and 100 (27.2%) had at least one HF re-hospitalization. Patients with serum HDL-C ≤ 0.90mmol/L had high body mass index, serum uric acid, NT-proBNP, C-reactive protein, glycosylated hemoglobin and prescribed with digoxin, and had lower serum albumin and left ventricular ejection fraction. Log-rank test analysis demonstrated that serum HDL-C ≥ 1.12mmol/L was associated with a significantly lower HF rehospitalization (P = 0.049) and all-cause mortality (P = 0.020). Cox multivariate analysis showed that serum HDL-C ≥ 1.12mmol/L was the independent risk factor for HF re-hospitalization (hazard ratio [HR]: 0.407; 95% confidence interval [CI]: 0.211 to 0.990; P = 0.047) and all-cause mortality (HR: 0.212; 95% CI: 0.068 to 0.659; P = 0.007).
Conclusions: In CRT patients, baseline serum HDL-C level was associated with clinical condition. Patients with serum HDL-C ≥1.12mmol/L had decreased risk of HF re-hospitalization and all-cause mortality.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Heart Failure and Cardiomyopathies: Heart Failure Gadgets Galore
Abstract Category: 14. Heart Failure and Cardiomyopathies: Therapy
Presentation Number: 1199-251
- 2017 American College of Cardiology Foundation