Author + information
- Gilson Fernandes,
- Amanda Fernandes,
- Rhanderson Cardoso,
- Manuel Rivera,
- Guilherme Nasi and
- Gustavo Soares Fernandes
Background: Vagus nerve stimulation (VNS) acts by providing augmentation of parasympathetic tone with the theoretical effect of inhibiting progression of heart failure. We aimed to perform a meta-analysis comparing VNS with medical therapy for the management of heart failure with reduced ejection fraction (HFrEF).
Methods: PubMed, Embase and the Cochrane Central Registry of Controlled Trials were searched for RCTs that compared VNS systems with guideline-directed medical therapy (GDMT) for management of HFrEF. Efficacy and safety data were summarized using fixed effect model predicting low heterogeneity between studies.
Results: Three RCTs were included, totalizing 575 patients treated with VNS and 373 patients on GDMT. VNS was associated with significant improvement of NYHA functional class (OR 2.36; p<0.01). Freedom from adverse events was observed in 89.4% of patients implanted with the device. There was no significant difference in mortality between groups (OR 1.32; p=0.21). VNS was associated with significant improvement of quality of life and exercise capacity on the individual studies.
Conclusions: VNS was shown to significantly improve the NYHA functional class of patients with HFrEF. VNS was safe, but there was no impact in terms of mortality benefit.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Heart Failure and Cardiomyopathies: Heart Failure Gadgets Galore
Abstract Category: 14. Heart Failure and Cardiomyopathies: Therapy
Presentation Number: 1199-254
- 2017 American College of Cardiology Foundation