Author + information
- Yan Jia,
- Wei Hu,
- Zhi-Yu Zhao,
- Hong-Ning Song,
- Jin-Ling Chen and
- Rui-Qiang Guo
Background: To assess the systolic function after renal sympathetic denervation by layer-specific two-dimensional speckle tracking imaging.
Methods: Twenty-three beagles were randomly divided into control group (eight dogs), URSD group (eight dogs) and RSD group (seven dogs). Control group were implanted with pacemakers without pacing; URSD group were implanted with pacemakers and underwent 3 weeks of rapid right ventricular pacing; and RSD group underwent catheter-based RSD bilaterally and were simultaneously implanted with pacemakers. All standard measurements were obtained from the left ventricular short-axis views at the levels of mitral annulus, papillary muscle and apex, and apical four-chamber, two-chamber, and long-axis views. The peak systolic longitudinal strain and circumferential strain of each layer of the left ventricle were measured by layer-specific two-dimensional speckle tracking imaging.
Results: After 3 weeks, all of the dogs in both the URSD and RSD groups showed lower left ventricular diastolic and systolic function compared with the control group, however, the dogs in the RSD group had a higher LV ejection fraction (LVEF) than the dogs in the RSD group(P<0.05). Compared with the control group, the global longitudinal strain, circumferential strain and radial strain all decreased significantly in URSD and RSD groups. The longitudinal strain of endo- and mid-cardium and the circumferential strain in endo- cardium were significantly higher in RSD group than in URSD group(P<0.05).
Conclusions: Myocardial systolic function is impaired in dogs with heart failure, layer-specific two-dimensional speckle tracking imaging can provide effective tools to assess the left ventricular systolic function. Renal sympathetic denervation can improve the myocardial systolic function in dogs with heart failure.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Novel Imaging and Therapies in Heart Failure
Abstract Category: 12. Heart Failure and Cardiomyopathies: Basic
Presentation Number: 1200-263
- 2017 American College of Cardiology Foundation