Author + information
- Kegan Moneghetti,
- Davide Stolfo,
- Jeffrey Christle,
- Yukari Kobayashi,
- Gherardo Finocchiaro,
- Gianfranco Sinagra,
- Jonathan Myers,
- Euan Ashley,
- Francois Haddad and
- Matthew Wheeler
Background: A hall mark of hypertrophic cardiomyopathy (HCM) is the heterogeneity of phenotype. Although HCM is often characterized by asymmetrical left ventricular hypertrophy, contemporary studies have focused on global assessment of left ventricular longitudinal strain (LS). We assessed whether measures of regional longitudinal systolic deformation are additive to established, validated measures of outcome.
Methods: A total of 131 patients with HCM who underwent cardiopulmonary exercise testing with echocardiography were included. Rest and stress global, septal and lateral LS were assessed and compared to 80 controls. Patients were followed for a median of 56 months (IQR 14-69) for the composite outcome of death, heart transplantation and septal reduction.
Results: All absolute LS components were significantly lower HCM patients (global 14.3±4.0% vs 18.8±2.2%, p<0.001; septal 11.9±4.9% vs 17.9±2.7%, p<0.001; lateral 16±4.7% vs 19.4±3.1%, p=0.001). Correlation analysis found E’ to be the strongest correlate of predicted peak oxygen consumption (ppVO2), (r=0.29, p<0.001). Lateral LS was the only independent predictor of outcome among strain variables along with indexed left atrial volume (LAVi) and ppVO2. Survival curves showed a poor outcome for patients with lateral LS<16.1%, LAVi>52ml/m2 and ppVO2<80%.
Conclusions: Assessment of regional LS is feasible and combined with ppVO2 and LAVi may be the optimal strategy for prognostic stratification in HCM.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Advances in HCM, PPCM and Other Cardiomyopathies
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1201-273
- 2017 American College of Cardiology Foundation