Author + information
- Margarita Chernovolenkoa,b,
- Omar Jimeneza,b,
- Sergio Teruyaa,b,
- Stephen Helmkea,b,
- Julissa Alvareza,b and
- Mathew Maurera,b
Background: Frailty is a clinical syndrome characterized by an increased susceptibility to adverse outcomes. Reversal of frailty with respect to the weight criterion is challenging in subjects with advanced heart failure in whom fluid retention confounds measurement of dry weight. We evaluated different definitions of the frailty score in patients enrolled in an ongoing study in frail older heart failure patients receiving left ventricular assist device (LVAD) therapy to determine if LVAD therapy will reverse frailty by each of these definitions.
Methods: Among older adult heart failure subjects (n=72, 22% women, 78% men, mean age 65 ± 12) with frailty assessed prior to LVAD placement, we evaluated five methods of assessing the weight criterion as part of the frailty phenotype. We determined whether the weight criterion differed based on the definition employed, and whether overall frailty scores changed based on weight method used.
Results: See table below. All methods show lower prevalence of frailty compared to the standard Change in Weight From Prior Year method by weight assessment alone. None of the methods differ with respect to the overall prevalence of frailty by assessment of all frailty criteria. Reversal of frailty appears time dependent and takes at least 3 to 6 months.
Conclusions: Different frailty criteria for weight change as part of the frailty phenotype do not impact overall frailty scores. The reversal of frailty after LVAD is time dependent with significant changes only after 3 to 6 months.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Heart Failure and Cardiomyopathies: What Next When All Else Is Failing?
Abstract Category: 14. Heart Failure and Cardiomyopathies: Therapy
Presentation Number: 1248-251
- 2017 American College of Cardiology Foundation