Author + information
- Pawel Rubis,
- Justyna Totoń-Żurańska,
- Sylwia Wisniowska-Smialek,
- Katarzyna Holcman,
- Paweł Wołkow,
- Ewa Wypasek,
- Joanna Natorska,
- Lucyna Rudnicka-Sosin,
- Agnieszka Pawlak,
- Artur Kozanecki and
- Piotr Podolec
Background: Relations between right ventricle (RV) and microRNAs in dilated cardiomyopathy (DCM) are poorly understood.
Methods: We studied 70 DCM patients (pts) (48 ± 12.1 years, EF 24.4 ± 7.4%). Basal RV (RVd1) > 41 mm and/or mid-cavity RV dimension (RVd2) > 35 mm was diagnostic for RV dilatation, and RV systolic dysfunction was diagnosed if TAPSE < 17 mm and/or RV tissue lateral systolic velocity (RV-S’) < 9.5 cm/s. Group 1 consisted of pts with normal and group 2 with abnormal RV dimensions and/or function. The expression of miR-21, miR-26, miR-29, miR-30 and miR-133a were measured in serum.
Results: Serum expression of all studied microRNAs did not differ between two groups (Table 1). MiR-30 correlated with RV outflow tract proximal diameter, RVd1, right atrial area, and pulmonary artery systolic pressure (r=0.28, p<0.02; r=0.36, p<0.005; r=0.46, p<0.001; r=0.35, p<0.002, respectively). MiR-21 correlated with RVd2 (r=-0.27, p<0.05) and miR-133a correlated with RV longitudinal diameter and RV wall thickness (r=-0.29, p<0.02; r=-0.24, p<0.05, respectively). Not a single microRNA correlated with TAPSE or RV-S’.
Conclusions: The expression of circulating microRNAs was similar in DCM patients regardless of RV dilation and/or systolic impairment. MiR-21, miR-30a, and miR-133a correlated with various RV morphological parameters, however, none of microRNAs correlated with RV systolic function indices. The observed relations between certain microRNAs and RV parameters in DCM warrant further studies.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Cardiac Fibrosis and Heart Failure: The Next Frontier
Abstract Category: 12. Heart Failure and Cardiomyopathies: Basic
Presentation Number: 1249-263
- 2017 American College of Cardiology Foundation