Author + information
- Oscar L. Rueda-Ochoaa,b,
- Marco A. Smiderle Gelaina,b,
- Jaap Deckersa,b,
- Dimitris Rizopoulosa,b,
- Klodian Dhanaa,b,
- Albert Hofmana,b,
- Oscar H. Francoa,b and
- Maryam Kavousia,b
Background: Diastolic dysfunction is an independent predictor of Heart Failure and all-cause mortality. Longitudinal studies evaluating sex-specific changes in left ventricular diastolic (LVD) function and its associated risk factors are scarce. We aimed to evaluate the changes in LVD parameters over a period of 11 years among women and men and the risk factors associated with them, from a large population-based cohort.
Methods: The study included 931 women and 688 men from the prospective population-based Rotterdam Study. Longitudinal changes in E wave, A wave, E/A ratio, Deceleration Time (DT), septal e’ and E/e'ratio were evaluated by echocardiography three times during a period of 11 years. To determine the risk factors associated with the change in each of the six indexes, a longitudinal data analysis using a marginal model was performed among men and women. The risk factors considered for inclusion in the models were age (time-varying covariate), systolic and diastolic blood pressure, heart rate, total and high-density lipoprotein (HDL) cholesterol, Diabetes mellitus (DM), coronary heart disease (CHD), smoking, body mass index (BMI), anti-hypertensive and lipid-lowering medication, and left ventricular mass.
Results: Mean (standard deviation) age of the population was 67.4 (5.0) years. Although women had poorer LVD function parameters, the tendency of longitudinal changes in LVD parameters during 11.1 years of follow-up was overall similar in both sexes. However, we observed some sex differences in the risk factors associated with the 6 LVF indexes. In particular, among women, CHD was associated with longitudinal changes in E wave (beta; 95% confidence interval: -6.74; -13.5,-0.02) and smoking with DT (8.37; 3.22, 13.5). Among men, DM was associated with longitudinal changes in A wave (3.99; 0.2, 7.8) and BMI with E/e'ratio (0.13; 0.07, 0.19).
Conclusions: In this population, women and men experienced the same tendency in longitudinal changes in LVD parameters over time. While CHD and smoking were strongly associated with longitudinal changes in some LVD parameters among women, the impact of metabolic disorders were more pronounced among men.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Developments in HFpEF and Arryhthmias
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1250-273
- 2017 American College of Cardiology Foundation