Author + information
- Yevgeniy Khariton,
- Yashashwi Pokharel,
- Michael Nassif,
- Yuanyuan Tang,
- Philip Jones,
- Suzanne Arnold and
- John Spertus
Background: Worse HF-specific health status, as assessed with the KCCQ, measured at any particular time point is prognostic of increased risk of death in patients with HFpEF. However, how to correctly interpret the prognostic significance of serial health status assessments, which are increasingly being done in outpatient clinics, is not known.
Methods: Using data from 1556 patients with HFpEF in the TOPCAT trial, we examined the association of KCCQ score with all-cause death using a series of multivariable Cox regression models. The independent association of KCCQ scores with mortality, alone at baseline, 4 and 12 months or with any 2 time points together was examined. A 5-point change in KCCQ is clinically significant.
Results: KCCQ scores at baseline, 4 months and 12 months were 60.1 ± 23.2, 67.5 ± 22.1 and 66.9 ± 23.5, respectively. Over a mean of 3.3 ± 1.4 years of follow, 20.4% of patients died. After adjusting for multiple demographic and clinical factors, lower KCCQ scores at each time point (when taken individually) were associated with increased mortality (Table). However, when analyzed together, only the most recent KCCQ score was significantly associated with outcomes while the earlier assessment was not.
Conclusions: The most recent health status assessment in HFpEF is more prognostic than earlier evaluations, suggesting that the KCCQ provides a dynamic risk estimation over time.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Developments in HFpEF and Arryhthmias
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1250-278
- 2017 American College of Cardiology Foundation