Author + information
- Manan Pareeka,b,
- Evan Fletchera,b,
- Muthiah Vaduganathana,b,
- Deepak L. Bhatta,b,
- Søren S. Petersena,b,
- Line R. Pedersena,b,
- Margrét Leósdóttira,b and
- Michael H. Olsena,b
Background: The aim of this study was to examine the differences in the prognostic ability of left ventricular hypertrophy (LVH) diagnosed by either electrocardiogram (ECG) or echocardiography.
Methods: We conducted a prospective population-based cohort study of 1,376 subjects without established cardiovascular disease, who underwent baseline 12-lead ECG (LVH defined by Sokolow-Lyon or Cornell criteria) and echocardiography (LVH defined by LV mass index). The ability of the two types of LVH for predicting the composite endpoint of coronary events, heart failure, stroke, and death from cardiovascular causes was assessed with Kaplan-Meier analyses and multivariable Cox proportional hazards models.
Results: Median age was 67 (IQR: 61-70) years, and 942 (68%) were male. Over a median follow-up of 8.9 (IQR: 8.3-9.7) years, 261 events occurred. In separate models, LVH on echocardiography (HR: 1.46 (95% CI: 1.10-1.94), p=0.01), but not ECG (HR: 1.30 (95% CI: 0.91-1.84), p=0.15), was associated with increased risk of events (Figure), after adjusting for baseline age, sex, smoking status, systolic blood pressure, total cholesterol, and use of antihypertensives. The prognostic importance of LVH, whether on ECG or echocardiography, was not affected by relative wall thickness or hypertension, i.e., blood pressure > 140/90 mmHg or use of antihypertensives (p>0.05 for all).
Conclusions: Echocardiographic, but not electrocardiographic, LVH predicts long-term cardiovascular events in older individuals.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Developments in HFpEF and Arryhthmias
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1250-296
- 2017 American College of Cardiology Foundation