Author + information
- Yashashwi Pokharel,
- Yevgeniy Khariton,
- Michael Nassif,
- Yuanyuan Tang,
- Philip Jones,
- Suzanne Arnold and
- John Spertus
Background: Heart failure-specific health status, as measured by the KCCQ, is prognostic of death or hospitalization in patients with HFrEF, both cross-sectionally and longitudinally. However, how best to interpret serial KCCQ data—which is occurring more frequently in clinical practice—is unknown.
Methods: In 1349 patients with HFrEF from the HF-ACTION trial, we examined the risk of all-cause death associated with KCCQ overall score: 1) cross-sectionally at baseline, 3 and 6 months and 2) combined at any 2 time points, using multivariable Cox regression models. A 5-point change in KCCQ is clinically significant.
Results: KCCQ scores at baseline, 3 and 6 months were 67.4 ±20.4, 71.7 ± 20.0 and 72.1 ± 20.9, respectively. 16.6% of patients died over a mean of 2.7 ± 1.0 years of follow up. Patients who died had poorer health status at all time points compared with those who survived. In adjusted models, every 5-point higher KCCQ score at each time point was associated with 4-7% lower death risk (Table). However, when assessed together, the most recent KCCQ score was independently associated with death, while the earlier assessment was not.
Conclusions: Although HF-specific health status measured at any time point is predictive of death in HFrEF, the most recent assessment is most predictive. This highlights the importance of serial health status assessment in HFrEF to obtain updated risk estimates.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Heart Failure and Cardiomyopathies: Heart Failure Is Just a Revolving Door
Abstract Category: 14. Heart Failure and Cardiomyopathies: Therapy
Presentation Number: 1293-243
- 2017 American College of Cardiology Foundation