Author + information
- Yoshiyuki Yazaki,
- Norihiro Kogame,
- Hiroki Niikura,
- Masahide Tokue,
- Nobutaka Ikeda,
- Raisuke Iijima,
- Hidehiko Hara,
- Masao Moroi and
- Masato Nakamura
Background: Anemia is associated with poor outcomes in patients with acute decompensated heart failure (ADHF). Whereas pseudoanemia with hemodilution due to fluid retention is also observed in ADHF patients. Thus, we investigated the association between hematocrit (Hct) and volume-overload with bioelectrical vectorial impedance analysis(BIVA).
Method and Results: This study enrolled 86 patients (74.3years, male 60.9%) admitted for ADHF in our hospital. At discharge, we assessed Hct and evaluated the extracellular water/total body water(ECW/TBW) by BIVA. 6-month outcomes focused on the events of rehospitalization. Median of ECW/TBW and Hct were 41.2%(IQR 34.7-45.4) and 35.7%(IQR 32.4-41.6). We divided to four groups according median of ECW/TBW and Hct. LowECW/TBW(<41.2%) and Low Hct(<35.7%) was defined as “true anemia”. HighECW/TBW(≥41.2%) and Low Hct(<35.7%) was defined as “pseudo anemia”. The result showed in the figure. After adjustment for covariates including age, male, CKD (eGFR<60mL/min/1.73 m2), LVEF and NT-proBNP, multivariate cox regression analysis identified that ”true anemia” was an independent predictor of rehospitalization (HR 30.3, p=0.004).
Conclusions: ADHF patients with “true anemia” was significantly poorer prognosis than those with “pseudoanemia”. A combination with evaluation of fluid volume by BIVA and hemoconcentration could stratify the high risk patients in ADHF.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: The Evolving World of LVADs, Transplant and Other Novel Discoveries
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1294-264
- 2017 American College of Cardiology Foundation