Author + information
- Peter Blomstranda,b,
- Peter Sjobloma,b,
- Martin Engvalla,b,
- Toste Lannea,b,
- Fredrik H. Nystroma,b,
- Carl-Johan Ostgrena,b and
- Jan Engvalla,b
Background: Obesity is associated with left ventricular (LV) diastolic dysfunction and heart failure but the relation to systolic dysfunction is unclear. The aim of the study was to explore the impact of obesity on LV function in patients with type 2 diabetes mellitus (T2DM).
Methods: We prospectively investigated 384 patients with T2DM, who participated in the CARDIPP study. The investigations included medical history and laboratory analyses. Echocardiography was performed at baseline and after four years. The patients were grouped according to body mass index (BMI), normal < 25, overweight 25-29 and obese if BMI > 30.
Results: Univariate linear regression showed that LV ejection fraction, LV mass and LV diastolic function expressed as E/é (i.e. the ratio between early diastolic transmitral flow and mitral annular motion velocities) were associated with BMI, βLVEF = -0.40, βLV mass = 0.50 and βE/é = 0.16, (p < 0.01). Demographic data or medical history did not differ between the BMI-groups. Patients with overweight and obesity had higher LV size, LV mass and impaired LV systolic and diastolic function compared to patients with normal weight (Table). Adverse remodelling with a reduction in LV ejection fraction or an increase in E/é or LV mass >20% compared to baseline was observed after four years in patients who had a further increase in BMI.
Conclusions: Overweight and obesity is associated with impaired LV systolic and diastolic function expressed as LV ejection fraction, LV mass and E/é in patients with T2DM.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: The Evolving World of LVADs, Transplant and Other Novel Discoveries
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1294-280
- 2017 American College of Cardiology Foundation