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Background: Several studies have shown that muscular strength is associated with an increased risk of mortality. Additionally, psoas muscle mass index (PMI) predicts mortality in cardiovascular surgery. The aim of this study was to investigate the relation between PMI and mortality in patient with heart failure with preserved ejection fraction (HFpEF).
Methods: We retrospectively reviewed 167 consecutive patients (mean age 69.9 ± 12.0 years, male 72.9%) who were hospitalized with HFpEF. Cross-sectional psoas muscles areas (PMA) at the level of the fourth lumbar vertebra were measured with CT. PMI was normalized for height. 166 patients were divided into 2 groups according to PMI. ROC curve was drawn to obtain the best cutoff value for PMI associated with 1 year mortality (cut-off value = 4.53). The primary endpoint was all-cause mortality at 1 year. Predictors for all-cause mortality were examined using Kaplan-Meier and multivariate analysis.
Results: The overall mortality at the end of the 1-year observational period was 15.0 %(25 patients). At 1-year follow-up, Kaplan-Meier survival rates showed that all-cause mortality was significantly higher in low PMI than high PMI patients (12.97% vs 0.98%, p < 0.001). Multivariate analysis demonstrated that the PMI was a significant predictor of all-cause mortality (P<0.05).
Conclusions: PMI was a predictor of 1-year mortality in patients with HFpEF. It can be considered a simple and reliable parameter for mortality risk in patients with HFpEF.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: The Evolving World of LVADs, Transplant and Other Novel Discoveries
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1294-290
- 2017 American College of Cardiology Foundation