Author + information
- Parham Zarrinia,b,
- Derek Leonga,b,
- Janet Weia,b,
- Galen Cook-Wiensa,b,
- Ahmed Al Badria,b,
- Carl Pepinea,b,
- Sheryl Kelseya,b,
- Eileen Handberga,b and
- C. Noel Bairey Merza,b
Background: Women with signs and symptoms of ischemia but no obstructive coronary artery disease (CAD) have an increased risk of developing heart failure (HF), which we have validated to be heart failure with preserved ejection fraction (HFpEF). We have previously demonstrated in this cohort of women with non-obstructive CAD that traditional risk factors for CAD (age, diabetes mellitus [DM], systolic blood pressure [SBP], and smoking) predict HFpEF hospitalizations. We aimed to identify additional risk factors for HFpEF hospitalizations in this unique cohort.
Methods: Using a multivariate Cox analysis, we assessed the association between baseline characteristics and the occurrence of HF hospitalizations in 509 women with signs and symptoms of ischemia with no obstructive CAD.
Results: During a median follow-up of 4-years, 22 women (mean age 57±9) were hospitalized for HFpEF. In multivariate analysis after adjusting for previously described risk factors for HFpEF (age, DM, SBP, smoking), the novel risk factors of Q wave in V1 and plasma progesterone level were associated with HFpEF hospitalization (Table).
Conclusions: In women with signs and symptoms of ischemia and no obstructive CAD, elevated plasma progesterone level was protective against developing HFpEF, while Q wave in V1 increased the odds of HF hospitalization. These data suggest that sex-specific risk variables should be investigated to better understand HFpEF pathogenesis.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: The Evolving World of LVADs, Transplant and Other Novel Discoveries
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1294-296
- 2017 American College of Cardiology Foundation