Author + information
- Ali Naqvi,
- Rola Khedraki,
- Jiawen Li,
- Li-Dek Chou,
- Tirunelveli Ramalingam and
- Pranav Patel
Background: Intravascular ultrasound (IVUS) and Optical Coherence Tomography (OCT) are imaging modalities used to guide coronary artery stenting, examine intravascular anatomy, and assess plaque morphology. While each has its limitations, a combined IVUS-OCT imaging sensor can exploit the high resolution of OCT and deep tissue penetration of IVUS. This integration can lower cost, reduce peri-procedural times and improve outcomes of percutaneous intervention. Currently, no such FDA-approved device exists.
Methods: We have now developed a fusion IVUS/OCT probe that possesses a 50 MHz IVUS sensor and a fiber-based OCT sensor that provides optimal speed and size. In order to assess its efficacy, we imaged the atherosclerotic plaque in the aorta of rabbits fed a high-cholesterol diet. These plaques were examined intravascularly using our catheter and results were corroborated with histopathology.
Results: This novel probe is able to collect IVUS images at a rate of 50 frames per second, improved from commercial IVUS systems. Additionally, it can independently obtain IVUS, OCT, or OCT-IVUS frames within the same site and with high sensitivity.
Conclusions: For the first time, we have developed a high-speed hybrid IVUS/OCT-imaging probe that will be useful in planning and assessing outcomes of percutaneous coronary intervention, including assessment of plaque composition and evaluation of thrombus and stent malapposition. Our long-term goal is to implement the device into human clinical trials.
Moderated Poster Contributions
Interventional Cardiology Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 4:00 p.m.-4:10 p.m.
Session Title: The Inside View: Learning From Intracoronary Imaging
Abstract Category: 23. Interventional Cardiology: IVUS and Intravascular Physiology
Presentation Number: 1175M-05
- 2017 American College of Cardiology Foundation