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We wanted to see if diabetics presenting with ACS had different outcomes requiring a modified approach, by comparing their outcomes to the non-DM counterparts.
We recruited 130 ACS patients each with DM and without DM, admitted to the ICCU at NIMS Hospital, Hyderabad, India. Relevant clinical, echo and laboratory parameters including eGFR at the time of admission were noted. At 15 days and 6 months and one-year follow-up, events (MACCE) if any were noted.
In the DM group, M: F was 2.6:1 with a mean age of 58.21 ± 11.46 years and had a mean eGFR of 72.77 ±25.20 ml/min/1.73 m2. In the non-DM group, M: F was 4.2: 1 with a mean age of 55.65 ± 12.56 years and had a mean eGFR of 147.2 ± 794 ml/min/1.73 m2. There was no correlation when age, sex, and eGFR were compared in both the groups (p-values=0.08, 0.1 and 0.3 respectively). 73 patients had LV dysfunction in DM group in comparison to 87 patients in non-DM group and they were statistically insignificant (z value=-1.8, p value=0.07). At one year follow-up, 5 patients had an event(s) in DM group in comparison to 4 patients in non-DM group and they were statistically insignificant (z value =1.2, p-value =0.23).
There was no difference in outcomes of ACS patients with or without DM. Probably the risk due ACS is high when compared to diabetes as a risk factor. There was also no difference in eGFR when compared in both the groups, may mean that in this study the DM patients are with end organ damage like a decrease in eGFR.