Treatment Effect of CRT-D Versus ICD in Comorbidity Groups
(A) Zero comorbidities, (B) 1 comorbidity, (C) 2 comorbidities, (D) ≥3 comorbidities. These 4 Kaplan-Meier curves divide the population by comorbidity group and compare probability of heart failure or death during 7 years of follow-up between treatment groups: implantable cardioverter-defibrillator (ICD) versus cardiac resynchronization therapy with defibrillator (CRT-D). In all cases, patients assigned to CRT-D had on average decreased probability of heart failure (HF) or death. This difference was statistically significant for the 1, 2, and ≥3 comorbidity groups. The greatest absolute risk reduction was observed in the groups with 2 or ≥3 comorbidities.