Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification
Mehdi Afshar, Kevin Luk, Ron Do, Line Dufresne, David S. Owens, Tamara B. Harris, Gina M. Peloso, Kathleen F. Kerr, Quenna Wong, Albert V. Smith, Mathew J. Budoff, Jerome I. Rotter, L. Adrienne Cupples, Stephen S. Rich, James C. Engert, Vilmundur Gudnason, Christopher J. O’Donnell, Wendy S. Post, George Thanassoulis and CHARGE Extracoronary Calcium Working Group
In Hispanic Americans in the MESA study, the triglyceride genetic risk score (GRS) was strongly predictive of triglyceride levels and also significantly associated with mitral annular calcium (MAC). This association could not be evaluated in African Americans or Chinese Americans, given that the triglyceride GRS was poorly predictive of triglyceride levels in these cohorts. AGES-RS = Age, Gene/Environment Susceptibility-Reykjavik Study; CHARGE = Cohorts for Heart and Aging Research in Genetic Epidemiology; CI = confidence interval; FHS = Framingham Heart Study; MESA = Multiethnic European Study of Atherosclerosis; OR = odds ratio.