Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers
The STOP-CHAGAS Trial
Carlos A. Morillo, Hetty Waskin, Sergio Sosa-Estani, Maria del Carmen Bangher, Carlos Cuneo, Rodolfo Milesi, Marcelo Mallagray, Werner Apt, Juan Beloscar, Joaquim Gascon, Israel Molina, Luis E. Echeverria, Hugo Colombo, Jose Antonio Perez-Molina, Fernando Wyss, Brandi Meeks, Laura R. Bonilla, Peggy Gao, Bo Wei, Michael McCarthy, Salim Yusuf, STOP-CHAGAS Investigators, Carlos Morillo, Sergio Sosa-Estani, Hetty Waskin, Brandi Meeks, Salim Yusuf, Rafael Diaz, Harry Acquatella, Julio Lazzari, Robin Roberts, Mahmoud Traina, Brandi Meeks, Laura R. Bonilla, Peggy Gao, Amanda Taylor, Iris Holadyk-Gris, Lindsey Whalen, M.C. Bangher, M.A. Romero, N. Prado, Y. Hernández, M. Fernandez, A. Riarte, K. Scollo, C. Lopez-Albizu, C.A. Cuneo, N.C. Gutiérrez, R.R. Milesi, M.A. Berli, M.H. Mallagray, N.E. Cáceres, J.S. Beloscar, J.M. Petrucci, H. Colombo, M. Dellatorre, Aldo Prado, W. Apt, I. Zulantay, L.E. Echeverría, D. Isaza, E. Reyes, F.S. Wyss, A. Figueroa, I. Guzmán Melgar, E. Rodríguez, J. Gascon, E. Aldasoro, E.J. Posada, N. Serret, I. Molina, A. Sánchez-Montalvá, J.A. Perez-Molina, R. López-Vélez and P.A. Reyes-López
BNZ Versus POS Versus Their Combination in Asymptomatic T. Cruzi Infection
Proportion of real-time polymerase chain reaction (RT-PCR) negative rates after 30 days and end of treatment (60 days), and at all follow-up visits per treatment allocation. RT-PCR negative conversion rates were significantly higher in all treatment arms compared with placebo (PLA) at 30 and 60 days (end of treatment), with only 10% treatment failure rates. However, once treatment was finished at 60 days, a marked drop in RT-PCR conversion rates was observed in the posaconazole (POS) monotherapy arm. This was similar to placebo rates, which continued to drop at 360 days to an overall RT-PCR–negative conversion rate of only 20% (80% treatment failure) compared with 95% (5% treatment failure) in the combination and benznidazole (BNZ) monotherapy arms. T. cruzi = Trypanosoma cruzi.