Renal Denervation: Effect on Renal Function and Blood Pressure
(A) Renal denervation (RDN) in sheep with hypertensive chronic kidney disease (CKD) significantly reduced blood pressure (mean arterial pressure [MAP]) and increased renal function (glomerular filtration rate [GFR]) compared with intact sheep. (B) However, RDN significantly impaired responses to hemorrhage, resulting in a greater fall in blood pressure (BP) during blood loss. Data are from 5 months post-RDN or sham procedure (2-month results were similar). DBP = diastolic blood pressure; SBP = systolic blood pressure.