Author + information
- Received May 14, 1985
- Revision received August 7, 1985
- Accepted August 16, 1985
- Published online January 1, 1986.
- Eric S. Nylen, MD*,
- Andrew I. Cohen, MD, FACC*,a,
- Marc H. Wish, MD*,
- John J. Lima, PharmD† and
- James D. Finkelstein, MD*
- ↵aAddress for reprints: Andrew I. Cohen, MD, Veterans Administration Medical Center, 50 Irving Street, N.W., Washington, D.C. 20422.
Acetylation is the major route of metabolism of many drugs including the antiarrhythmic agent procainamide. Coadministration of para-aminobenzoic acid was observed to decrease the biotransformation of procainamide to N-acetylprocainamide in a patient with rapid acetylation kinetics. In view of the distinct antiarrhythmic and toxic properties of procainamide and N-acetylprocainamide,the observed drug interference may have great clinical relevance in long-term oral antiarrhythmic therapy and in instances where other drugs converge for acetylation.
- Received May 14, 1985.
- Revision received August 7, 1985.
- Accepted August 16, 1985.
- American College of Cardiology Foundation