Author + information
- Received May 7, 1985
- Revision received October 30, 1985
- Accepted November 8, 1985
- Published online April 1, 1986.
- Nobuyoshi Tomioka, MD,
- Chiharu Kishimoto, MD,
- Akira Matsumori, MD and
- Chuichi Kawai, MD, FACCa
- ↵aAddress for reprints: Chuichi Kawai, MD, The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyo-ku, Kyoto 606, Japan.
The effect of prednisolone on viral myocarditis was studied in BALB/c mice with encephalomyocarditis virus myocarditis. Prednisolone was injected intramuscularly, 10 mg/kg once a day, on days 4 to 13 (experiment 1) and on days 8 to 17 (experiment 2). The control mice in each experiment received injections of distilled water.
In experiment 1, myocardial virus titers were maximal but neutralizing antibodies were rarely present on day 4, and viral titers were still elevated and antibody titers were high on day 8. The survival rate of the prednisolone group was significantly lower (p < 0.05) than that of the control group on days 21, 22 and 23. On day 10, the antibody titers of the prednisolone group were significantly lower (p < 0.01) than those of the control group, and viral titers of the prednisolone group remained significantly elevated (p < 0.01), whereas viruses were rarely isolated in the control group. In experiment 2, the survival rate and antibody titers were not significantly different in the prednisolone and control groups. In both experiments, no viruses were isolated on day 14.
This work was supported in part by a research grant for the study of intractable diseases from the Ministry of Health and Welfare of Japan, Tokyo, Japan.
- Received May 7, 1985.
- Revision received October 30, 1985.
- Accepted November 8, 1985.
- American College of Cardiology Foundation