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We aim to discover the role of acute myocardial infarction (AMI). To explore whether the low expression of ABCC4 in peripheral blood can be the molecular marker in the genetic evaluation of acute myocardial infarction or not and to discuss the possible mechanism of ABCC4 gene involved in the pathogenesis of AMI.
In this research, peripheral blood of 77 patients with acute myocardial infarction and 72 people with non-coronary heart disease were collected. Real-time fluorescent quantitative PCR test was used to measure expression quantity of ABCC4 gene at the mRNA level.
The result indicates that rat the RNA level, expression quantity of ABCC4 gene in peripheral blood of patients with acute myocardial infarction is obviously lower than that in the control group. Binary Logistic regression analysis indicates that: Low expression of ABCC4 gene serves as the independent risk factor for progression of acute myocardial infarction. Low expression of ABCC4 gene is irrelevant to Gensini score of coronary artery and cardiac troponin. Result of creation of ROC curve by using expression quantity of ABCC4 gene at the mRNA level indicates that: When relevant expression quantity of ABCC4 gene at the mRNA level in peripheral blood is used as the criterion for diagnosis of acute myocardial infarction, its sensitivity, specificity, positive predictive value and negative predictive value are 0.494, 0.679, 57.61% and 60.32% respectively.
ABCC4 gene has a low expression in peripheral blood of patients with acute myocardial infarction, and low expression of ABCC4 gene serves as an independent risk factor for occurrence of acute myocardial infarction. Low expression of ABCC4 gene in peripheral blood increases the risk of acute myocardial infarction by 2.066 times. Expression quantity of ABCC4 gene can be used as a genetic marker indicating the risk of occurrence of acute myocardial infarction.