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Implantable cardioverter-defibrillator (ICD) has become the first-line therapy for prevention of sudden cardiac death (SCD). Controversial results still exist regarding the effectiveness of ICD in non-ischemic heart failure.
The PubMed, Embase, and Cochrane Central databases were searched for randomized trials comparing ICD in combination with medical treatment versus medical treatment for non-ischemic heart failure. The primary endpoint was incidence of all-cause death. We derived pooled risk ratios (RRs) with fixed-effects models.
Five studies enrolling 2573 patients were included. Compared with medical treatment, ICD with medical treatment was associated with a significantly lower risk for all-cause mortality (RR: 0.83; 95% confidence interval [CI]:0.71 to 0.97).
Compared with medical treatment only, ICD in combination with medical treatment reduces all-cause mortality.