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Although serum uric acid (SUA) levels have been shown to be related to several cardiovascular diseases, the association of SUA with premature ventricular contraction (PVC) has not been fully examined. The aim of the present study was to investigate the association of SUA with PVC prevalence.
We studied the relationship between SUA and the prevalence of PVC among 98,965 subjects (79,034 males, mean age: 51.9 ± 12.6 years) in the Kailuan cohort study (n=101,510, age range: 18-98 years) from June 2006 to October 2007. SUA levels were determined using the uricase-peroxidase method at baseline, and PVC was diagnosed by 12-lead electrocardiography. The subjects were divided into six groups. Subjects without PVC were assigned in the control group, while the remaining subjects were assigned into five groups based on their SUA levels. A multivariate logistic regression model was constructed to evaluate the association between SUA and PVC prevalence.
The prevalence of PVC was 1.1% in total subjects, 1.1% in male subjects, and 1.0% in female subjects. Compared with the first quintile of SUA, the odds ratio (OR) and 95% confidence interval (95% CI) of other quintiles were 1.33 (1.05-1.69), 1.14 (0.90-1.46, 1.37 (1.08-1.74) and 1.63 (1.30-2.06) in male subjects, 1.12 (0.68-1.87), 1.27 (0.77-2.09), 1.45 (0.90-2.36) and 1.33 (0.81-2.18) in female subjects, and 1.30 (1.04-1.61), 1.20 (0.96-1.50), 1.33 (1.07-1.66) and 1.57 (1.26-1.95) in total subjects, respectively. The correlation between SUA and PVC prevalence were significant in total subjects and in male subjects, but not in female subjects. This relationship remained significant between SUA and PVC prevalence after excluding subjects with a history of myocardial infarction or stroke.
We demonstrated that SUA was apparently associated with the PVC prevalence. The significant relationship between SUA and PVC identified in male subjects suggest the potential involvement of a gender-specific mechanism. Prospective researches are needed to further corroborate our results.