Author + information
- Yu-Long Xia,
- Jing Zhao,
- Wei Ma,
- Lin Xue,
- Jie Jiang,
- Yong Huo and
- Jing Zhou
Urotensin II(UII) is a vasoconstrictive peptide widely expressed in human cardiovascular system. The role of UII in cardiovascular disease was complex and the correlation between UII and different types of AF is not so clear. The aim of this study is to compare plasma levels of Urotensin II (UII) in paroxysmal and persistent atrial fibrillation (AF) and different sites in AF patients.
The study enrolled 47 patients with paroxysmal AF, 42 patients with persistent AF and 37 gender- and age-matched control subjects consecutively from Department of Cardiology, Peking University First Hospital from May 2015 to February 2016. Blood samples were collected from cubital vein in the morning in all patients after an overnight fast the day after hospitalization. The Coronary Sinus(CS), Right Atrium(RA) and Left Atrium(LA) blood were collected in 8 AF patients (5 paroxysmal AF, 3 persistent AF) during radiofrequency ablation (RFA) therapy under the same protocol. An enzyme immunoassay were performed for the measurement of UII. The relationship between UII with atrial fibrillation were analyzed by statistical methods including univariate and multivariate logistic regression.
The patient population comprised of 126 patients, in which 85(67.5%) were diagnosed with hypertension and 99(78.6%) were diagnosed with dyslipidemia. There were no differences in demographic features, comorbidities and drug use except for oral anticoagulation drug in the three groups. Plasma levels of UII(ng/ml) were 6.68 (3.69-11.33), 4.95 (3.55-11.63), 10.84 (5.31-27.13) accordingly in paroxysmal AF, persistent AF and no atrial fibrillation controls. There was a significant increase in the plasma levels of UII between no atrial fibrillation controls with either paroxysmal (p=0.010) or persistent AF patients group (p=0.002). No differences of plasma UII were seen in two atrial fibrillation sub-groups (p=1.000). The plasma levels of UII(ng/ml) were 4.28 (2.23-11.34), 4.09 (2.54-11.53), 9.12 (3.48-13.13), 3.70 (2.36-10.94) accordingly in peripheral vein, RA, CS and LA. No differences of plasma UII were seen in different sites of AF patients (p=0.771). Atrial fibrillation was significantly associated with BNP [OR (95%CI)=1.015 (1.003-1.027), P=0.017] and LVAI [OR (95%CI)=1.099 (1.009-1.196), P=0.029] in multivariate analysis, while inversely associated with UII [OR (95%CI)=0.932 (0.876-0.992), P=0.027].
In a population comprised of a comparatively greater proportion of patients with hypertension and dyslipidemia, plasma levels of UII were increased in no atrial fibrillation controls compared to patients with atrial fibrillation. No differences of plasma UII were seen in atrial fibrillation sub-groups or in different sites of atrial fibrillation patients. UII was inversely associated with the development of atrial fibrillation.