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Comparison treatment effect of WenXinKeLi(WXKL) and ShenSongYangXin(SSYX) in Patients with atrial fibrillation(AF), in order to providing the evidence of the reasonable clinical application.
“AF and WXKL” “AF and SSYX” is retrieved in CNKI, VIP, WanFang database, Elsevier science, Medline, PubMed, ProQuest. Selection criteria:1. literature on meta-analysis and systematic evaluation in public journal;2.The treatment group give single drug or combined antiarrhythmic western medicine(AWM);3.For repeatedly published literature, selected the recent one. Exclusion criteria:1. Non-meta-analysis and non-systematic evaluation literature. 2. Using WXKL and SSYX or having other confounding factors, such as combining other Chinese medicine;3.No control group literature; 4.Meeting or thesis. At least two researchers categorized and sort out the selected literature, and compared in the general situation of the literature, the treatment effect, the adverse reactions and so on.
1.By reading the title, abstract and text, we finally selected four literature about WXKL (English 1), six literature about SSYX (English 1).
2.There are 50 articles in the four selected literatures about WXKL, including 3925 cases(treatment group:1919, control group: 2006). There is one literature about paroxysmal AF, one literature about various types of AF, the others didn’t described the type of AF. One literature give WXKL combined with conventional western medicine(CWM),such as aspirin,irbesartan etc,(control group: corresponding CWM or amiodarone). The rest literatures give WXKL combined with AWM (control group: corresponding AWM). There are 102 articles in the six selected literatures about SSYX, including 7907 cases (treatment group: 4128, control group:3779). There is one literature about the various types of AF, the others about paroxysmal AF. Three literatures give SSYX combined with CWM(control group: corresponding CWM). The rest literatures give SSYX combined with AWM(having only SSYX including one article) (control group: corresponding AWM). The quality levels of these literatures are low (2 literatures didn’t described).
3.WWKL and SSYX have the effect of treatment patients with AF, which can reduce the AF frequency, maintain sinus rhythm, improve symptoms, improve P wave dispersion, but it is particularly prominent WXKL in controlling the ventricular rate and turning sinus rate, while SSYX in improving cardiac function, cutting back left atrial diameter, enhancing quality of life and reducing the AF frequency.
They have a good effect on treatment AF, WWKL or SSYX whether alone or in combination with CWM and AWM, which are safety and have no obvious adverse reactions. But they are difference between various types of AF and treatment index. Due to the small number of samples, it is necessary for the objective evaluation of both WXKL and SSYX to be further study of scholars.