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The present study was aimed at evaluating the impact of changes in uric acid levels on blood pressure (BP) control during 3.9 years in hypertensive elderly patients.
A total of 465 elderly hypertensive patients, who were re-hospitalized at Fujian Provincial Hospital between August 2010 and January 2014, were selected for the retrospective cohort study. Multiple regression analysis was used to analyze the relationship between serum uric acid levels and BP control at baseline and 3.9 years later.
The mean age of patients was 68.3 ± 9.7 years at baseline and the mean follow-up period was 3.9 (3.0-7.0)years. After adjustment for factors such as antihypertensive drugs, body mass index, blood lipids and renal function, multiple regression analysis showed that the baseline uric acid had linearly positive correlation with systolic and diastolic BP 3.9 years later (P<0.05). Each 100 μmol l-1 elevated uric acid at baseline resulted in an increase of 2.2 mmHg in systolic BP[95% confidence interval (CI): 0.3-4.1] and an increase of 3.5 mmHg (95% CI: 2.2-4.8) in diastolic BP 3.9 years later. Patients with new-onset hyperuricemia and those with uncontrolled hyperuricemia had greater risk for poor BP control, compared to those patients with normal uric acid (odds ratio: 2.004, 95% CI: 1.018-3.946, and 2.629, 95% CI: 1.399-4.939, respectively).
The elevated uric acid was an independent risk factor for poor BP control in elderly hypertensive subjects. The decline of uric acid level may contribute to long-term BP control.