Author + information
The purpose of this study is to determine the effect of aerobic exercise training on LV diastolic function in Chinese young male primary hypertensive patients stage 1.
Thirty-two hypertensive individuals, which were diagnosed mild blood pressure elevated (blood pressures ranging from 140 to 159 mmHg systolic and/or 90 to 99 mmHg diastolic)aged between 25 and 40 years were enrolled. Subjects were trained on a Cycle Ergometer at an intensity of 75%HR max, for 45 min, five times per week (about 2000kcal) and 12 weeks in total. 24 hours ambulatory blood pressure (ABP), heart rate were measured at baseline and at the end of aerobic exercise. Diastolic function (left atrium dimension, peak E and A velocities, E/A ratio, isovolumic relaxation time, and deceleration time) and MPI were evaluated by simultaneous transmitral and transaortic spectral Doppler flow velocities. Systolic function was evaluated by shortening fraction and ejection fraction.
Significance of the training effects were evaluated by comparing the pre- and post-training measures (p < 0.05). 12 weeks of aerobic exercise training resulted in a 10-mmHg and 6-mmHg respectively reduction of SBP(143±8 to 131±12; P<0.001) and DBP(87±6 to 82±10; P=0.01). Reductions of 4bpm was also seen in HR (75±8 to 71±7; P<0.001). The significant lowering at week 12 were found in Cardiac structural parameters, LA(34.6±4.2mm to 32.4±3.4mm, P<0.001), LAi(22.4±5.7 ml/m2 to 20.1±5.1 ml/m2, P=0.011), LVDd (50.2±5.6 mm to 48.3±4.5 P=0.002,), IVSd (10.7±1.5mm to 10.2±1.2 mm, P=0.001), LVMI (73.7±16.9 g/m2 to 65.7±14.1 g/m2, P<0.001),compared to baseline. There were no statistically significant differences in Cardiac functional parameter(LVEF,E, A, E/A ratio, Lateral e’, Lateral a’, lateral E/e’ ratio) for the group between pre- and post-training. There were statistically significant reductions in Cardiac time intervals, IVRT(87±15ms to 74±10ms, P<0.001), IVRT/ET(0.34±0.06 to 0.27±0.05, P=0.002) and MPI (0.57±0.07 to 0.48±0.07, P<0.001) between pre-and post-training.
Moderate intensity aerobic exercise has been proven to prevent hypertension and to help in the management of stage 1 hypertension and improve LV diastolic function.