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Adiponectin, which is specifically secreted by adipose tissue, has been shown to have an anti-atherosclerotic effect and to improve insulin resistance (IR). The aim of this study was to determine the correlations between adiponectin, insulin resistance and atherosclerosis in Non-diabetic hypertensive patients and healthy volunteers.
In this randomized controlled clinical study, complete demographic characteristics were obtained and several laboratory measurements were collected from all enrolled subjects. The HOMA-IR was calculated as an insulin sensitivity index. Atherogenic index of plasma (AIP), which is calculated as log (TG/HDL-C), was a significant predictor of atherosclerosis, better than LDL-C. The plasma concentrations of adiponectin, IL-6, MCP-1 and MMP-9 were determined using ELISA. All data were analyzed using SPSS 13.0 software.
A total of 309 participants were enrolled in the study. The hypertensive patients with IR (n=93) displayed significantly higher levels of HOMA-IR and AIP, in addition to lower adiponectin levels, compared to the patients without IR (n=121) and the healthy adults (n=95) (P<0.05). Furthermore, the circulating IL-6, MCP-1 and MMP-9 concentrations differed significantly between the hypertensive patients and healthy adults (P<0.05). Additionally, inverse trends between the adiponectin and IL-6, MCP-1, MMP-9, HOMA-IR and AIP values were found in the clinical study. After adjusting for confounders via multivariate linear regression, the HOMA-IR, adiponectin and Scr values remained independently associated with AIP for all participants.
Adiponectin plays a role in dyslipidemia and may correlate with atherosclerosis either directly or indirectly by improving insulin resistance and inhibiting inflammation.