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Estrogen-related receptor alpha (ERRα, gene name ESRRA), which acts as transcription factor, plays a role in modulating renal sodium-potassium metabolism-related ion channel expression and regulating blood pressure (BP). The aim of the study was to assess the association between genetic variants in ERRα and blood pressure responsiveness to sodium and potassium in a family-based sample.
334 individuals from 124 families were selected from rural areas in Northern China. Participants underwent a sequential 3 days baseline survey, 7 days of low salt (NaCl 3g/day or 51.3mmol/day of sodium), 7 days of high salt (NaCl 18g/day or 307.8mmol/day of sodium) and 7 days of high sodium with potassium supplementation (KCl 4.5g/day or 60mmol/day of potassium).
SNP rs493052 of the ESRRA gene was associated with diastolic BP (DBP) and mean arterial pressure (MAP) responses to high-salt intervention. In addition, SNP rs620645 was associated with systolic BP (SBP), DBP and MAP responses to low-salt intervention and at baseline. However, there’s no association between selected SNPs in the ESRRA gene and BP response to high-salt-plus-potassium diet reached statistical significance.
Our study concludes that genetic variants in the ESRRA gene are associated with BP responses to dietary sodium intervention.