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Hypertrophic cardiomyopathy (HCM) is a disease predisposes to unexplained left ventricular (LV) hypertrophy and dysfunction and non-dilated ventricular chambers associated unusual myocardial mechanics. The most serious complications of HCM is sudden death for young subclinical patients, thus, observing and analyzing LV strain has particular values of diagnostic and prognostic for young HCM patients. The objective of this study was to determine which strain component assessed by 2-dimensional speckle-tracking echocardiography (2DSTE) and 3-dimensional speckle-tracking echocardiography (3DSTE) was the most powerful predictor for young HCM.
We enrolled 96 young subjects (45 HCM (32 males; 25 ± 6 yrs) and 41 controls (27 males; 26 ± 4 yrs)) underwent TTE performed strain analysis using both 2DSTE and 3DSTE. Two-dimensional and 3-dimensional global longitudinal, circumferential, and radial strain and global 3-dimensional strain of the LV were measured in each patient using QLab and TOMTEC software by two-independent-specialists.
Data analysis for the new 3D-STE methodology: (-21.94 ± 3.4% vs 27.8 ± 5.1%, P > 0.001 (2D GLS), -19.3 ± 3.4% vs 26.3 ± 4.2%, P < 0.001 (3D GLS), -85.2±43.7% vs 106.3 ± 26.82%, P < 0.001 (3D GRS), -30.7 ±5.7% vs 34.3 ± 6.4%, P > 0.001, (3D GCS), respectively. 3D GLS but not GRS, GCS significantly correlated with LVMI, E/Ea and LVOT-PG (P<0.05) in young HCM subjects.
LV global 3D systolic strain analysis using the new 3D-STE methodology is feasible and reproducible. 3D GLS is more sensitive index than 2DGLS for young HCM.