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To explore the application of a macrovascular corrosion casting technique via ABS perfusion in clarifying the spatial relationship between cardiac chambers in the fetal human heart.
Cardiovascular casting via ABS perfusion was performed for 28 fetal hearts, including 18 obtained from induced labor after permission due to congenital heart disease prenatally diagnosed by fetal ultrasound and10 normal ones obtained from induced labor due to other non-cardiac causes.
A total of 28 fetal cardiovascular casts were successfully prepared. The 10 normal fetal hearts generally showed a top-bottom spatial relationship between the atrium and ventricle at both the left and right sides, and a left-right spatial relationship between the two ventricles as well as between the two atriums. However, among the 18 fetal hearts with complex congenital heart diseases, one heart had a front-back spatial relationship between the left atrium and ventricle, three had a left-right spatial relationship between the right atrium and ventricle, and others showed a normal top-bottom atrium-ventricle relationship. In addition, one heart had a front-back spatial relationship between the left and right atriums, 12 hearts had a front-back spatial relationship between the left and right ventricles, two hearts had a top-bottom spatial relationship between the left and right ventricles, while others showed a normal left-right relationship of the ventricles or atriums between the two sides.
Clarification of the spatial relationship between cardiac chambers in the fetal heart helps us understand the anatomical structure of the heart. Macrovascular corrosion casting can serve as an effective tool to intuitively and three-dimensionally demonstrate the spatial relationship between cardiac chambers of a heart with complex congenital heart disease. This technique can provide us with further information regarding the connection between the spatial relationship of cardiac chambers and congenital heart abnormalities to improve accuracy of ultrasonic diagnosis, thereby possessing important clinical significance to surgical treatment.