Author + information
- 1Department of Healthcare Clinic, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- 2Department of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- 3Department of Orthopaedics, Huangpu district of the first affiliated hospital of Sun Yat-sen University, Guangzhou, China
To study the correlation between the changes of N-terminal pro-brain natriuretic peptide (NT-proBNP) and coronary lesion (CAL) in children with Kawasaki disease (KD), and to explore the clinical significance of early diagnosis of KD and predicting CAL.
43 children with KD were enrolled in our hospital from January 2012 to December 2015. Among them, 24 cases (48.8%) of typical Kawasaki disease (TKD), incomplete Kawasaki disease (IKD) 19 cases (44.2%). According to the presence or absence of coronary artery damage, KD group was divided into coronary artery lesion (CAL) group (20 cases) and no coronary artery damage (nCAL) group of 23 cases. All children were measured plasma NT-proBNP levels, parallel routine clinical biochemical tests, KD group of children with acute heart line color Doppler ultrasound examination. A total of 45 cases of upper respiratory tract infection with fever symptoms were enrolled in the control group in our Pediatric emergency department during the same period. Statistical analysis: SPSS18.0 software was used to compare the changes of plasma NT-proBNP level in each group, and the ROC curve of NT-proBNP was analyzed and the optimal threshold value of CAL was obtained. Pearson correlation analysis was used to investigate the correlation between NT-proBNP and other clinical biochemical tests.
The serum NT-proBNP was (156.7 ± 24.1) ng / L in the control group, (1852.1 ± 235.4 ng / L in the TKD group and 1903.1 ± 357.4 ng / L in the IKD group) (P <0.01). There was no significant difference between TKD group and IKD group (P> 0.05). The serum NT-proBNP was (916.7 ± 157.4) ng / L in the nCAL group and (1337.9 ± 328.4) ng / L in the CAL group, and the difference was statistically significant (P <0.01). There was a positive correlation between serum NT-proBNP and white blood cell count and CRP (r = 0.231, P <0.01); r = 0.40 (P <0.01), negatively correlated with albumin and serum sodium (r = -0.387 (P <0.05). The area under the curve was 0.790, the sensitivity was 82.8% and the specificity was 78.3%, with the NT-proBNP 945.9 ng / L as the cutoff value.
The level of plasma NT-proBNP in acute phase is helpful for the early diagnosis of KD, and it can predict the occurrence of CAL.