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To investigate the accuracy of ultrasound RF-based technique detecting the early changes of arterial elasticity in control and atherosclerotic high risk group and compared with IMT which has been commonly accepted as an indicator of atherosclerosis.
160 participants (46 in control group and 114 in atherosclerotic high risk group) were detected the compliance coefficient (CC) ,distensibility coefficient (DC) ,α stiffness coefficient (α),β stiffness coefficient (β) and single point pulse wave velocity (PWV). Evaluation methods and indexes are as follows, (1) the relationship between IMT and arterial wall elastic parameters, (2) the difference of arterial wall elastic parameters in participants with IMT＜1.0mm, (3) the difference of arterial wall elastic parameters in participants with IMT＜1.0mm grouping with the number of risk factors, (4) the independent affecting factors of arterial wall elastic parameters.
IMT negatively correlated with DC and CC, positively correlated with α,β,and PWV,and the correlation coefficient were -0.396,-0.347,0.452,0.452 and 0.518,separately (P＜0.050). In participants with IMT＜1.0mm (n=153) ,compared to the control group, DC, CC decreased,α, β and PWV increased (P<0.01). DC, α, β and PWV differed along with the number of atherogenic risk factors (P<0.05) ,contrast to CC (P＞0.05). Age was the most important influence factor for arterial wall elastic parameters, followed by systolic pressure and pulse pressure, and the other influence factors were dyslipidemia, hypertension, smoking, type IIdiabetes and overweight.
The arterial wall elastic parameters measured by the ultrasound RF-based technique correlated well with IMT. And they can sensitively reflected the differences of carotid artery wall elastic parameters. This technique is expected to reflect early atherosclerosis.