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To investigate the relationship between serum Uric Acid (UA) level and carotid artery arteriosclerosis in patients with impaired glucose tolerance (IGT).
Serum UA of 176 IGT patients (male: 86, female: 90) were detected. High frequency ultrasound was used to detect IMT and plaques. According to the results of high frequency ultrasound, the 176 cases were divided to three groups (groups A, B and C) according to carotid artery ultrasonometry IMT (group A: IMT≤0. 9 mm; group B: 0. 9 mm < IMT <1.3 mm; group C: IMT≥1.3 mm or plaques formation). The correlation between the level of UA and carotid artery disease was analyze.
The serum UA levels of group A were significantly lower than the other two groups (P <0. 05). After adjusting for age, gender, smoking, LDL, systolic blood pressure, body mass index, total cholesterol, triglyceride and C - reactive protein (CRP), logistic regression analysis showed that the serum UA level was an independent risk factor for carotid atherosclerosis and carotid artery IMT (P<0.05). Spearman analysis showed that, serum UA was positively correlated with TG (r =0. 395, P = 0. 000) and hs - CRP (r =0. 162, P =0. 031), but was negatively correlated with HDL - C (r = -0. 236, P =0. 003). Serum UA was almost positively correlated with BMI (r =0. 158, P =0. 053).
Serum UA level is a risk factor for carotid atherosclerosis in patients with IGT. Body weight and lipids metabolism disorder may contribute to the incidence of hyperuricemia in patients with IGT.