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To compare the clinical and the angiographic characteristics of the Korean-Chinese and Han nationality with coronary heart disease (CHD) in Yanbian area in China.
The risk factors and distribution of culprit vessels of coronary artery were retrospectively analyzed in 753 cases of CHD. The levels of plasma nitric oxide (NO) and the protein of endothelial nitric oxide synthase (eNOS) were measured by Elisakit (Cusabio).
Alcohol consumption was significantly higher in Korean-Chinese than in Han patients. No difference was observed in other risk factors between two groups. The numbers of stenotic coronary arteries were significantly higher in Korean-Chinese patients. Plasma NO and eNOS were significantly lower in Korean-Chinese patients.
There are significant differences in the angiographic characteristics and the levels of plasma NO and eNOS between Korean-Chinese and Han patients with CHD in Yanbian area in China. Reduced eNOS may be responsible for increased stenotic coronary arteries in Korean-Chinese CHD patients compared to Han in Yanbian area in China. Mechanistic link between alcohol consumption and eNOS/NO deficiency or angiographic abnormality needs further investigation.