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High-sensitivity C-reactive protein (hs-CRP) has been demonstrated to be a useful marker of the presence and extent of coronary atherosclerosis. Patients with mix plaque (MP) or non-calcified plaque (NCP) have a higher risk of poor outcomes. However, the relationship between hs-CRP and presence of NCP or MP (NCP & MP) in Chinese population remain unclear. We investigated the role of hs-CRP in predicting the presence of NCP & MP in Chinese population undergoing coronary computed tomography angiography (CCTA).
A total of 868 subjects were recruited and the clinical and laboratory data were collected. Coronary plaques were classified as calcified, non-calcified and mixed. According to whether the subjects had coronary atherosclerotic plaques and the characteristic of the most stenotic plaque, subjects were divided into no plaque (NP), calcified plaque (CP) and NCP & MP. There were 219 subjects who had no NP, 331 patients with CP, 207 patients with NCP and 111 patients with MP. NCP & MP were more prone to occur poor outcomes, therefore, patients with NCP & MP were merged for analysis.
Patients with NCP & MP had significantly higher hs-CRP level than those with NP or CP (1.99 [1.01-3.83] vs. 1.56 [0.84-2.81] or 1.56 [0.86-3.23] mg/L, p < 0.05). The subjects were divided into 2 groups according to the median hs-CRP level: high hs-CRP group and the low hs-CRP group. The percentage of patients with NCP & MP in the high hs-CRP group was significantly higher than those in the low hs-CRP group (42.5% vs. 30.9%, p < 0.05). Spearman correlation analysis showed that hs-CRP was positively correlated with triglyceride (r = 0.092, p < 0.05), while negatively correlated with high-density lipoprotein-cholesterol (r = -0.195, p < 0.001). Multiple logistic regression analysis showed that hs-CRP level was an independent risk factor for the presence of NCP & MP (OR: 1.05; 95% CI: 1.01-1.09; p = 0.022).
Higher hs-CRP level is independently linked with the presence of NCP & MP in Chinese population.