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To verify whether there is a positive correlation between NLR and PWV and to explore factors that influence PWV in young SLE patients.
A total of 90 female patients with SLE who were enrolled in the Chinese SLE Treatment and Research group (CSTAR) registry were included in this cross-sectional investigation. Traditional and non-traditional cardiovascular risk factors were assessed on the same day that brachial-ankle PWV (baPWV) was examined. The patients were divided into three subgroups according to the tertiles of their mean baPWV values. SPSS 20.0 was used to perform all statistical analyses in this study. Both univariate linear regression and multivariate regression models were utilized to analyze the association between NLR and arterial stiffness.
Systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglycerides (TGs) were all significantly different among the three groups, as were creatinine (CR) and blood urea nitrogen (BUN). All the groups exhibited homogenous body mass index (BMI), fasting blood glucose (FBG), and glycosylated hemoglobin (HbA1c) values, and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were comparable. The median disease activity was significantly higher in group three (10.50) than in groups one (4.00) and two (4.00). The white blood cell (WBC) count and neutrophil count were significantly different among the three groups, while the lymphocyte count was comparable; therefore, the resulting NLRs were different among the groups. The full list of independent predictors for PWV consisted of DBP, the SLE disease activity index (SLEDAI) and NLR.
In conclusion, we demonstrated that there was a positive correlation between NLR and PWV. Moreover, we found that disease activity and DBP also positively correlated with PWV.