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Ultrasound alone or combined with contrast agent microbubbles offers wide-spread applicability, ranging from well-established diagnostic tools to adjunctive therapeutic methods. Ultrasound could elicit anti-inflammatory and tissue stimulating effects, as already shown in clinical trials and experimentally. Several reports have demonstrated that ultrasound affects cells that are centrally involved in the immune response. However, the mechanism of this effect, we still unknown.
Using experimental database mining and statistical analysis methods we developed the following findings.
1) Microbubbles can enhance exosome delivery by ultrasound cavitation effect on increasing immunosuppressive cellular permeability in cardiovascular tissue; 2) Various anti-inflammatory molecules including microRNAs and anti-inflammatory cytokines and chemokines can mediate the anti-inflammatory effects of immunosuppressive cell-derived exosomes by microbubbles enhanced ultrasound cavitation in cardiovascular tissue.
Our results suggest that exosomes are potential novel mediators for microbubbles enhanced ultrasound cavitation-induced in cardiovascular tissue anti-inflammatory therapies.