Author + information
- Miaoling Li1
Vandetanib is an orally active anti-tumor drug that is used for the treatment of certain tumors of the thyroid gland. It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor and the epidermal growth factor receptor .however, vandetanib can prolong the QT interval, the exact mechanism remain unknown.
Langendoff perfusion technique isolated guinea pig heart was used to record ECG and intraventricular pressure, whole-cell patch clamp technique was used to record the HERG current.
Vandetanib concentration dependently slowed down the heart rate and prolonged QT interval, duration of QRS wave and QTc .Heart rate was significantly decreased, and the QTc duration was increased inhibited, compared with the control group.Moreover, the ventricular pressure difference decreased significantly. With Vandetanib, both IhERG,tail and IhERG,step were completely inhibited.
The findings revealed that Vandetanib caused heart toxicity through targeted the herg channel, eventually slowly heart rate, prolonged QTc duration and decreased the intraventricular pressure.