Author + information
- Yousef Rasmi1,
- Fereshteh Ghaffari1,
- MirHossein SeyedMohammadzad2,
- Alireza Rostamzadeh2 and
- Elmira Roshani1
Cardiac syndrome X [CSX] is characterized by the presence of chest pain, positive exercise test and normal angiography in coronary arteries. Although the cause of the syndrome is still unknown, studies suggest that microvascular coronary dysfunction plays a crucial role in its pathogenesis. Research has shown that circulating endothelial microparticles (EMPs) are novel marker for endothelial dysfunction that they contribute to the severity and progression of vascular disease. The aim of this study was to compare the level of endothelial microparticles among patients with cardiac syndrome x and healthy control subjects.
Forty patients with CSX and 19 healthy controls were enrolled. Two groups were matched for BMI and sex. We evaluated the level of EMP markers by flowcytometery using CD31, CD41 and CD62 monoclonal antibodies in the peripheral blood of patients and control subjects. Clinical and laboratory factors associated with EMPs were assessed.
CD31+/41- endothelial microparticle counts and percent were 4.43±3 counts/μL and 0.262±0.29 in CSX patients versus 1.56±0.8 counts/μL and 0.058±0.04 in healthy control (p<0.05). Percent of CD62E in CSX were significantly higher than control subjects (p<0.05). CD31+41+ platelet microparticle counts and percent were significantly higher in CSX patients compared with control subjects. There was no significantly correlation between risk factors of cardiovascular disease and EMPs in CSX patients but levels of hs-CRP correlated with PMP positively.
Our findings show that the circulating level of EMPs and PMPs increase in CSX patients.