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To evaluate the effect of RND on the systemic, renal and cardiac sympathetic nerve system (SNS) and Renin–Angiotensin–Aldosterone System (RAAS) after an acute myocardial infarction in Chinese Mini-swine.
Anterior MI was induced in 24 Chinese mini-swine by transient balloon occlusion of left anterior descending coronary artery for 1.5 hours. After reperfusion for 2 hours, the swine were randomly assigned to receive bilateral catheter-based RDN (the RDN group) or sham-denervation (the sham group) and were studied up to 8 weeks. The activity of the systemic, renal and cardiac sympathetic nerve would be determined by measuring the concentration of noradrenaline (NE), epinephrine (E) in peripheral vein plasma, venae renales plasma and tissue at baseline，directly after RDN and after 8 weeks. In parallel, the activity of RAAS would be determined by measuring plasma and tissue concentration of renin (PRA), angiotensin-II (AII) and aldosterone (Ald).
7 swines died in the modeling process, 3 in RDN group and 4 in sham group. There were no differences between two groups in the peripheral vein plasma and venae renales plasma concentration of NE, E, PRA, AII, Ald at baseline. After 8 weeks, concentration of peripheral vein plasma Ald differed in the RDN and sham groups (0.08±0.03 vs. 0.19 ± 0.5, p=0.001). Venae renales PRA (2.05 ± 1.73 vs.0.19 ± 0.21, p=0.037), E (0.07±0.01 vs.0.05±0.01, p=0.048) significantly decreased compared with baseline in the RDN group. Both Venae renales PRA and AII raised post MI and fell to baseline post RDN. Furthermore, there were no differences between the RDN and sham group in PRA, AII, Adl of the cardiac tissue, nor in NE, E, PRA, AII, Adl in renal tissue.
Venae renales plasma biochemical indicators are more sensitive compared with the peripheral vein in co-related with RDN process. Besides, more easily performed clinical measurements are needed to confirm the procedural success, i.e. that RDN indeed leads to sufficient disruption of renal nerves.