Author + information
The present meta-analysis compared the effect of exercise-only to exercise-diet interventions on plasma glucose levels among a pre-diabetic population.
A literature search was conducted using PubMed, EMBASE and Cochrane databases. The Cochrane Collaboration tool was used to assess the quality of each trial. Two reviewers independently performed quality assessment of all included articles. A random effects model was used to calculate the pooled effect and funnel plot show the publish bias.as conducted to
A total of 4,021 participants from 12 studies were included in this meta-analysis, 2,045 of them were in the intervention group and 1,976 were in the control group. Compared to the exercise-only interventions, the exercise-diet interventions showed a significant effect on decreasing fasting plasma glucose levels, with a weighted mean difference (WMD) =-0.22 mmol/L, 95%CI:-0.25,-0.18 (Z=12.06，P<0.05). The subgroup effect of exercise-only interventions did not produce a statistically significant result (WMD=-0.09 mmol/L，95%CI:-0.18,0.00, Z=1.91, P>0.05). According to the intervention periods, the pooled effect in≥2 years group was the highest and its WMD (95% CI) was -0.24 mmol/L (-0.43,-0.05). The pooled effects were statistically significant among the elderly, and those of American and European descent, with WMD (95% CI) being -0.19 mmol/L(95%CI:-0.22,-0.15), -0.17 mmol/L (-0.21,-0.12) and -0.22 mmol/L(-0.27,-0.17), respectively.
Evidence from published trials indicates that exercise-diet interventions showed a significant effect on decreasing fasting plasma glucose levels.