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The retrospective study was designed to analyze the dynamic relationship between the metabolic syndrome (MS), MS components and the progression of the coronary artery lesion.
Patients who underwent a second coronary angiography or coronary 320-slice CTA at a minimum interval of 6 months after their first examination in the Third Affiliated Hospital of Sun Yat-sen University from 2010 to 2015 (n=245), were divided into non-MS group and MS group, non-progression group and progression group, non-notable progression group and notable progression group. We compared the difference of clinical data and Biochemical index among groups, at the same time, we survey the relationship though Regression analysis.
The rate of Gensini score progression (7.69±15.13 VS 2.45±7.64, P=0.003) and the incidence of notable progression （59.1% VS 45.2%, P =0.037） of group MS were significantly higher than the non-MS group’s. The incidence of MS were correlated with the notable progression of the coronary artery lesion positively （OR=1.75, 95%CI：1.03-2.97, P =0.038）in single-variate logistic regression analysis. The incidence of hypertension were correlated with the progression （OR=2.60, 95%CI：1.44-4.70, P =0.002） and the notable progression （OR=3.36, 95%CI：1.82-6.22, P <0.001）of the coronary artery lesion positively in multivariate logistic regression analysis.
The progression of coronary artery lesion was faster in MS group. Hypertension may be the major risk factor for the progression of coronary lesion in MS components.