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To estimate the predicted risk of developing type 2 diabetes mellitus (T2DM) in men with different risk of cardiovascular complications.
The study included 300 men aged 40-59 years with low-moderate (<5% SCORE), high (5-10% SCORE) and very high (> 10% SCORE) cardiovascular risk. The criterion for exclusion was the presence of CVD and T2DM. Patients were questioned, measured blood pressure (BP) and heart rate (HR), anthropometric indicators. Biochemical parameters were determined: lipid profile, immunoreactive insulin, uric acid, highly sensitive C reactive protein, fasting glucose level and 2 hours after load. All subjects underwent cardiovascular risk assessment using the electronic version of the European SCORE scale. The forecast for the development of T2DM was determined using the FINDRISC questionnaire.
According to the data, among the surveyed men with different levels of cardiovascular risk on the SCORE scale, the highest number of people with a low risk of diabetes was found among men with a low and moderate cardiovascular risk, which is 54.0%. Every fifth patient with a low risk of developing diabetes has a high cardiovascular risk, whereas among people with a low risk of diabetes, men with a very high cardiovascular risk are found in 9.1% of cases. Among those with a moderately increased risk of diabetes, men with a low and moderate cardiovascular risk are 32.0%, the incidence of high cardiovascular risk is 38.6%, and the proportion of patients with a very high cardiovascular risk is 26.3%. The highest number of men with a high and very high risk of developing diabetes had a very high cardiovascular risk - 64.6%. Individuals with a high and very high risk of developing diabetes 40.6% had a high cardiovascular risk, whereas those with a low and moderate cardiovascular risk accounted for 14.0%. Analysis of the status of carbohydrate metabolism in groups of men with different levels of cardiovascular risk revealed a tendency to increase the frequency of pre-diabetes in patients with high and very high cardiovascular risk. In the group of men with low and moderate cardiovascular risk, pre-diabetes is detected in 21% of cases. Among those with high cardiovascular risk, pre-diabetes is detected in 40% of cases. In the group of very high cardiovascular risk, normal tolerance to glucose is found only in 38% of cases.
Thus, the study showed that individuals with a very high risk on the SCORE scale also have a high risk of developing T2DM in the next 10 years for the FINDRISC questionnaire. It is necessary to continue further studies to identify the risk of developing T2DM in individuals at risk of developing cardiovascular pathology, since the prevention of these conditions several times will reduce the number of complications and deaths from CVD.