Author + information
- 1Clinical Research Center, the first Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China
- 2Department of Emergency Medicine, the Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China
- 3Department of Cardiology, the Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China
The aim of the study was to evaluate the association of daytime napping durations with cardiovascular diseases (CVDs) in a community-based population.
In this prospective cohort study (ClinicalTrials.gov Identifier: NCT00005275), 1196 individuals (698 males and 498 females, 71.2±9.5 years) with CVDs as primary outcome and 3849 non-CVD individuals (1651 males and 2198 females, 61.6±10.6 years) were analyzed prospectively in CVD group and non-CVD group. The daytime napping durations were recorded according to the baseline interview. CVDs including angina, myocardial infarction, stroke, heart failure, hypertensive heart disease and heart arrhythmia were recorded at the end of the follow-up visit. Logistic regression analysis was used to count the odds ratios (OR) and 95% confidence intervals (CI) for the relationship between daytime napping durations and CVDs.
A total of 347 individuals (229 males and 118 females) taking daytime napping were found in CVD group while 722 (464 males and females) in the non-CVD group. There was statistically significant difference between CVD group and control group in daytime napping (29.0% vs. 18.8%; p=0.033). After multivariate logistic regression analysis, daytime napping duration≥45min/day (OR 1.561; 95% CI 1.227-1.984; p<0.001), age (OR 1.084; 95% CI 1.075-1.092; p<0.001) and hypertension (OR 2.131; 95% CI 1.836-2.475; p<0.001) were associated with the incidence of CVDs.
Daytime Napping duration longer than 45 mins may be responsible for the increased risk for CVDs in normal population. However, further clinical trials are needed to investigate the underlying mechanisms.